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    7/1/2013· In the plant kingdom, SAM works as a primary biological methyl (CH 3) donor, notably required for polyamine production and for the regulation of a number of essential cellular processes such as cell division, synthesis of chlorophyll, and maintenance of integrity of cell walls and membranes. 20 The synthesis of Met is tightly regulated ...

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  • Comparative Developmental Neurotoxicity of Organophosphate ...

    5/1/2006· Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA A comparative approach to the differences between systemic toxicity and developmental neurotoxicity of organophosphates is critical to determine the degree to which multiple mechanisms of ...

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  • Heat Shock Factor 1 Is a Substrate ... - PubMed Central (PMC)

    9/15/2016· Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent phenethyl isothiocyanate (PEITC) inhibits ...

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    Resuspend the cell pellet through gentle shaking movements and add 12 mL warm Powell medium including 120 μL CaCl 2 (1 mmol/L). Centrifuge for a third time at 16×g for 1 min. Again, discard the supernatant. All these steps can be seen on .

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    Tumour necrosis factor-α (TNF-α) deficient mice (TNF-α−/− mice) are resistant to skin carcinogenesis. Cellular signalling via the transcription factor complex AP-1 is thought to play a key ...

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    iron deficiency, a highly prevalent micronutrient deficiency affecting more than 30% pregnancies worldwide is a consequence of maternal iron deficiency anemia, hypertension, diabetes mellitus, or cigarette smoking during pregnancy (14, 22, 52, 65, 66).Fetal iron deficiency results in short- and long-term cognitive and behavioral abnormalities in humans including an increased risk of ...

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  • Heat Shock Factor 1 Is a Substrate ... - PubMed Central (PMC)

    9/15/2016· Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent phenethyl isothiocyanate (PEITC) inhibits ...

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    Dibenzoylmethane (DBM), a minor β-diketone constituent of licorice, has been shown to exhibit antineoplastic effects in prostate cancer cell lines by induction of cell cycle arrest and regulation of androgen receptor expression. In the present study, we investigated the in vitro and in vivo efficacy of DBM using TRAMP-C1 cell lines and TRAMP mice.

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    A quantitative comparison of the export characteristics of NLS-PK and NLS-PK-RNP/GR (Figure 6C) illustrated that the presence of the RNP and GR do- mains of nucleolin strongly inhibited nuclear export of NLS-PK: while 450/0 of NLS-PK had reached the cytoplasm 8 hr after nuclear injection, only 10% of the NLS-PK-RNP/ GR protein had been able to ...

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